Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis.

@article{Levi2013GeneticAO,
  title={Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis.},
  author={Liraz Levi and Glenn P. Lobo and Mary Kathryn Doud and Johannes von Lintig and Darcie D. Seachrist and Gregory P Tochtrop and Noa Noy},
  journal={Cancer research},
  year={2013},
  volume={73 15},
  pages={
          4770-80
        }
}
The fatty acid-binding protein FABP5 shuttles ligands from the cytosol to the nuclear receptor PPARβ/δ (encoded for by Pparδ), thereby enhancing the transcriptional activity of the receptor. This FABP5/PPARδ pathway is critical for induction of proliferation of breast carcinoma cells by activated epidermal growth factor receptor (EGFR). In this study, we show that FABP5 is highly upregulated in human breast cancers and we provide genetic evidence of the pathophysiologic significance of FABP5 in… CONTINUE READING
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Molecular determinants of retinoic acid sensitivity in pancreatic cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2012
View 8 Excerpts
Highly Influenced

The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology.

The International journal of developmental biology • 2011
View 5 Excerpts
Highly Influenced

Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARbeta/delta to RAR.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 4 Excerpts
Highly Influenced

Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 5 Excerpts
Highly Influenced

The anti-apoptotic role of PPARβ contributes to efficient skin wound healing

The Journal of Steroid Biochemistry and Molecular Biology • 2003
View 5 Excerpts
Highly Influenced