Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis.

@article{Levi2013GeneticAO,
  title={Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis.},
  author={Liraz Levi and Glenn P. Lobo and Mary Kathryn Doud and Johannes von Lintig and Darcie D. Seachrist and Gregory P Tochtrop and Noa Noy},
  journal={Cancer research},
  year={2013},
  volume={73 15},
  pages={
          4770-80
        }
}

• Liraz Levi, Glenn P. Lobo, +4 authors Noa Noy
• Published 2013 in Cancer research
• DOI:10.1158/0008-5472.CAN-13-0384

The fatty acid-binding protein FABP5 shuttles ligands from the cytosol to the nuclear receptor PPARβ/δ (encoded for by Pparδ), thereby enhancing the transcriptional activity of the receptor. This FABP5/PPARδ pathway is critical for induction of proliferation of breast carcinoma cells by activated epidermal growth factor receptor (EGFR). In this study, we show that FABP5 is highly upregulated in human breast cancers and we provide genetic evidence of the pathophysiologic significance of FABP5 in… CONTINUE READING

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