Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis.

@article{Germain2010GeneticAO,
  title={Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis.},
  author={Mitchel Germain and Ad{\`e}le De Arcangelis and Stephen D Robinson and Marianne Baker and Bernardo Tavora and Gabriela D'Amico and Rita Silva and Vassiliki Kostourou and Louise E Reynolds and Alan E. Watson and Janet Louise Jones and Elisabeth Georges-Labouesse and Kairbaan M Hodivala-Dilke},
  journal={The Journal of pathology},
  year={2010},
  volume={220 3},
  pages={370-81}
}
Laminins are expressed highly in blood vessel basement membranes and have been implicated in angiogenesis. alpha6beta1- and alpha6beta4-integrins are major receptors for laminins in endothelial cells, but the precise role of endothelial alpha6-integrin in tumour angiogenesis is not clear. We show that blood vessels in human invasive ductal carcinoma of the… CONTINUE READING