Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.

@article{Longbottom2009GeneticAO,
  title={Genetic ablation of retinal pigment epithelial cells reveals the adaptive response of the epithelium and impact on photoreceptors.},
  author={Rebecca E Longbottom and Marcus Fruttiger and Richard H. Douglas and Juan Pedro Martinez-Barbera and John Greenwood and Stephen E Moss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 44},
  pages={
          18728-33
        }
}
The retinal pigment epithelium (RPE) plays a critical role in the maintenance of the outer retina. RPE cell death or dysfunction drives the pathophysiology of many retinal diseases, but the physiological response of the retina to RPE cell loss is poorly understood, mainly because of the absence of suitable experimental models. Here, we generated a transgenic mouse in which an inducible Cre recombinase is expressed exclusively in the RPE under the control of the monocarboxylate transporter 3… CONTINUE READING

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