Genetic ablation of neural crest cell diversification.

@article{Arduini2009GeneticAO,
  title={Genetic ablation of neural crest cell diversification.},
  author={Brigitte L. Arduini and Kevin M. Bosse and Paul D. Henion},
  journal={Development},
  year={2009},
  volume={136 12},
  pages={1987-94}
}
The neural crest generates multiple cell types during embryogenesis but the mechanisms regulating neural crest cell diversification are incompletely understood. Previous studies using mutant zebrafish indicated that foxd3 and tfap2a function early and differentially in the development of neural crest sublineages. Here, we show that the simultaneous loss of foxd3 and tfap2a function in zebrafish foxd3(zdf10);tfap2a(low) double mutant embryos globally prevents the specification of developmentally… CONTINUE READING
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