Genetic ablation of hypocretin neurons alters behavioral state transitions in zebrafish.

  title={Genetic ablation of hypocretin neurons alters behavioral state transitions in zebrafish.},
  author={Idan Elbaz and Laura Yelin-Bekerman and Julian Nicenboim and Gad Vatine and Lior Appelbaum},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={32 37},
Sleep is an essential biological need of all animals studied to date. The sleep disorder narcolepsy is characterized by excessive daytime sleepiness, fragmentation of nighttime sleep, and cataplexy. Narcolepsy is caused by selective degeneration of hypothalamic hypocretin/orexin (HCRT) neurons. In mammals, HCRT neurons primarily regulate the sleep/wake cycle, feeding, reward-seeking, and addiction. The role of HCRT neurons in zebrafish is implicated in both sleep and wake regulation. We… CONTINUE READING
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The orexin/hypocretin system: physiology and pathophysiology

  • S Nishino, T Sakurai
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