Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.

@article{GaveriauxRuff2011GeneticAO,
  title={Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.},
  author={Claire Gaveriaux-Ruff and Chihiro Nozaki and Xavier Nadal and Xavier C Hever and Raphael Weibel and Audrey Matifas and David S Reiss and Dominique Filliol and Mohammed A. Nassar and John N Wood and Rafael Maldonado and Brigitte Lina Kieffer},
  journal={Pain},
  year={2011},
  volume={152 6},
  pages={1238-48}
}
Opioid receptors are major actors in pain control and are broadly distributed throughout the nervous system. A major challenge in pain research is the identification of key opioid receptor populations within nociceptive pathways, which control physiological and pathological pain. In particular, the respective contribution of peripheral vs. central receptors remains unclear, and it has not been addressed by genetic approaches. To investigate the contribution of peripheral delta opioid receptors… CONTINUE READING
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