Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response.

@article{Sinnayah2006GeneticAO,
  title={Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response.},
  author={Puspha Sinnayah and Eric Lazartigues and Koji Sakai and Ram V. Sharma and Curt D. Sigmund and Robin L. Davisson},
  journal={Circulation research},
  year={2006},
  volume={99 10},
  pages={1125-31}
}
The subfornical organ (SFO) of the brain has long been considered a critical integrating center for the cardiovascular actions of the renin-angiotensin system (RAS). Early reports of angiotensin II (Ang II) immunoreactivity in the SFO and its neural projections to downstream cardiovascular nuclei raised the possibility that Ang II is produced locally and functions as a putative neurotransmitter in these circuits. However, evidence of functionally significant de novo synthesis of Ang II in the… CONTINUE READING