Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis.

@article{Kaftanovskaya2015GeneticAO,
  title={Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis.},
  author={Elena M. Kaftanovskaya and Carolina Lopez and Lydia Ferguson and Courtney B. Myhr and Alexander I. Agoulnik},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2015},
  volume={29 6},
  pages={
          2327-37
        }
}
It is commonly accepted that androgen-producing fetal Leydig cells (FLC) are substituted by adult Leydig cells (ALC) during perinatal testis development. The mechanisms influencing this process are unclear. We used mice with a retinoid acid receptor 2 promoter-Cre recombinase transgene (Rarb-cre) expressed in embryonic FLC precursors, but not in postnatal testis, and a dual fluorescent Cre recombinase reporter to label FLC and ALC in vivo. All FLC in newborn testis had the recombinant, whereas… CONTINUE READING

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