Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice.

@article{Duong2012GeneticAO,
  title={Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice.},
  author={Tam Q. Duong and Steven T Proulx and Paola Luciani and Jean-Christophe Leroux and Michael Detmar and Peter Koopman and Mathias Francois},
  journal={Cancer research},
  year={2012},
  volume={72 12},
  pages={
          3105-14
        }
}
The lymphatic vasculature provides a major route for tumor metastasis and inhibiting neolymphangiogenesis induced by tumors can reduce metastasis in animal models. Developmental biology studies have identified the transcription factor SOX18 as a critical switch for lymphangiogenesis in the mouse embryo. Here, we show that SOX18 is also critical for tumor-induced lymphangiogenesis, and we show that suppressing SOX18 function is sufficient to impede tumor metastasis. Immunofluorescence analysis… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS, ESTIMATED 42% COVERAGE

59 Citations

051015'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 59 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

Similar Papers

Loading similar papers…