Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice.

@article{Duong2012GeneticAO,
  title={Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice.},
  author={Tam Duong and Steven T Proulx and Paola Luciani and Jean-Christophe Leroux and Michael Detmar and Peter Koopman and Mathias Francois},
  journal={Cancer research},
  year={2012},
  volume={72 12},
  pages={3105-14}
}
The lymphatic vasculature provides a major route for tumor metastasis and inhibiting neolymphangiogenesis induced by tumors can reduce metastasis in animal models. Developmental biology studies have identified the transcription factor SOX18 as a critical switch for lymphangiogenesis in the mouse embryo. Here, we show that SOX18 is also critical for tumor-induced lymphangiogenesis, and we show that suppressing SOX18 function is sufficient to impede tumor metastasis. Immunofluorescence analysis… CONTINUE READING