Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma.

@article{Hafeez2011GeneticAO,
  title={Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma.},
  author={Bilal Bin Hafeez and Weixiong Zhong and Jamey Weichert and Nancy Ellen Dreckschmidt and Mohammad Sarwar Jamal and Ajit K. Verma},
  journal={Cancer research},
  year={2011},
  volume={71 6},
  pages={2318-27}
}
Protein kinase C epsilon (PKCε), a novel PKC isoform, is overexpressed in prostate cancer (PCa) and correlates with disease aggressiveness. However, the functional contribution of PKCε to development or progression of PCa remained to be determined. Here we present the first in vivo genetic evidence that PKCε is essential for both the development and metastasis of PCa in the transgenic mouse model of prostate adenocarcinoma (TRAMP). Heterozygous or homozygous genetic deletions of PKCε in FVB/N… CONTINUE READING