Genetic ablation of IGFBP-2 suggests functional redundancy in the IGFBP family.

Abstract

Gene targeting allows mutations to be introduced selectively into any mouse locus of interest. This approach has already been used to demonstrate that insulin-like growth factor (IGF) peptides and receptors are required in vivo for normal prenatal growth. One of the IGFBP genes, IGFBP-2, has also been disrupted using gene targeting, and homozgyous null BP-2… (More)

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Cite this paper

@article{Pintar1995GeneticAO, title={Genetic ablation of IGFBP-2 suggests functional redundancy in the IGFBP family.}, author={John E. Pintar and A. Schuller and J A Cerro and Maureen E. Czick and Andy Grewal and B N Green}, journal={Progress in growth factor research}, year={1995}, volume={6 2-4}, pages={437-45} }