Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation.

@article{Egea2008GeneticAO,
  title={Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation.},
  author={Joaquim Egea and Christian Erlacher and Eloi Monta{\~n}ez and Ingo Burtscher and Satoru Yamagishi and Martin Hess and Falko Hampel and Rodrigo S{\'a}nchez and Mar{\'i}a Teresa Rodr{\'i}guez-Manzaneque and Michael R. B{\"o}sl and Reinhard F{\"a}ssler and Heiko Lickert and Ruediger Klein},
  journal={Genes & development},
  year={2008},
  volume={22 23},
  pages={3349-62}
}
During early mouse development, the anterior visceral endoderm (AVE) secretes inhibitor and activator signals that are essential for establishing the anterior-posterior (AP) axis of the embryo and for restricting mesoderm formation to the posterior epiblast in the primitive streak (PS) region. Here we show that AVE cells have an additional morphogenetic function. These cells express the transmembrane protein FLRT3. Genetic ablation of FLRT3 did not affect the signaling functions of the AVE… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Cell Adhesion Molecules

Advances in Neurobiology • 2014
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…