Genetic Versus Pharmacological Assessment of the Role of Cannabinoid Type 2 Receptors in Alcohol Reward-Related Behaviors.

@article{Powers2015GeneticVP,
  title={Genetic Versus Pharmacological Assessment of the Role of Cannabinoid Type 2 Receptors in Alcohol Reward-Related Behaviors.},
  author={Matthew S. Powers and Kristen R Breit and Julia A. Chester},
  journal={Alcoholism, clinical and experimental research},
  year={2015},
  volume={39 12},
  pages={
          2438-46
        }
}
BACKGROUND Emerging evidence suggests that the endocannabinoid system (ECS) is involved in modulating the rewarding effects of abused drugs. Recently, the cannabinoid receptor 2 (CB2R) was shown to be expressed in brain reward circuitry and is implicated in modulating the rewarding effects of alcohol. METHODS CB2 ligands and CB2R knockout (KO) mice were used to assess CB2R involvement in alcohol reward-related behavior in 2 well-established behavioral models: limited-access 2-bottle choice… CONTINUE READING
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