Genetic Variations in the Regulator of G-Protein Signaling Genes Are Associated with Survival in Late-Stage Non-Small Cell Lung Cancer

@inproceedings{Dai2011GeneticVI,
  title={Genetic Variations in the Regulator of G-Protein Signaling Genes Are Associated with Survival in Late-Stage Non-Small Cell Lung Cancer},
  author={Jingyao Dai and Jian T Gu and Charles Lu and Jie Lin and David J. Stewart and David W. Chang and J. L. A. Roth and X ianchao Wu},
  booktitle={PloS one},
  year={2011}
}
The regulator of G-protein signaling (RGS) pathway plays an important role in signaling transduction, cellular activities, and carcinogenesis. We hypothesized that genetic variations in RGS gene family may be associated with the response of late-stage non-small cell lung cancer (NSCLC) patients to chemotherapy or chemoradiotherapy. We selected 95 tagging single nucleotide polymorphisms (SNPs) in 17 RGS genes and genotyped them in 598 late-stage NSCLC patients. Thirteen SNPs were significantly… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2015

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Tumour necrosis factor and cancer

Nature Reviews Cancer • 2009
View 6 Excerpts
Highly Influenced

Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…