Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function.

@article{Jrgensen2017GeneticVI,
  title={Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function.},
  author={Stine Lundgaard J\orgensen and Christian Theil Have and Christina R Underwood and Lars Dan Johansen and Petrine Wellendorph and Anette Prior Gjesing and Christinna V J\orgensen and Shi Quan and Gao Rui and Asuka Inoue and Allan Linneberg and Niels Grarup and Wang Jun and Oluf Pedersen and Torben Hansen and Hans Br{\"a}uner-Osborne},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 4},
  pages={1524-1534}
}
GPRC6A is a G protein-coupled receptor activated by l-amino acids, which, based on analyses of knock-out mice, has been suggested to have physiological functions in metabolism and testicular function. The human ortholog is, however, mostly retained intracellularly in contrast to the cell surface-expressed murine and goldfish orthologs. The latter orthologs are Gq-coupled and lead to intracellular accumulation of inositol phosphates and calcium release. In the present study we cloned the bonobo… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS