Genetic Variations Affecting Serum Carcinoembryonic Antigen Levels and Status of Regional Lymph Nodes in Patients with Sporadic Colorectal Cancer from Southern China

@inproceedings{Liang2014GeneticVA,
  title={Genetic Variations Affecting Serum Carcinoembryonic Antigen Levels and Status of Regional Lymph Nodes in Patients with Sporadic Colorectal Cancer from Southern China},
  author={Yu Liang and Weizhong Tang and Tiqiang Huang and Yong Gao and Aihua Tan and Xiaobo Yang and Haiying Zhang and Yan-ling Hu and Xue Qin and Shan Li and Shijun Zhang and Linjian Mo and Zhenjia Liang and Deyi Shi and Zhang Huang and Yingyong Guan and Jicheng Zhou and Cheryl A. Winkler and Stephen J. O'Brien and Jianfeng Xu and Zengnan Mo and Tao Peng},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Serum carcinoembryonic antigen (sCEA) level might be an indicator of disease. Indeed, an elevated sCEA level is a prognostic factor in colorectal cancer (CRC) patients. However, the genetic determinants of sCEA level in healthy and CRC population remains unclear. Thus we investigated the genetic markers associated with elevated serum sCEA level in these two populations and its clinical implications. METHODS AND FINDINGS Genome-wide association study (GWAS) was conducted in a cohort… CONTINUE READING