# Genetic Variation of the β2-Adrenoceptor

@article{Taylor2001GeneticVO,
title={Genetic Variation of the $\beta$2-Adrenoceptor},
author={D. Taylor and M. Kennedy},
journal={American Journal of Pharmacogenomics},
year={2001},
volume={1},
pages={165-174}
}
• Published 2001
• Biology
• American Journal of Pharmacogenomics
Asthma is a polygenic disease for which no clear genotype-phenotype relationships have emerged. In contrast, although not associated with the diagnosis of asthma per se, variant forms of the β2-adrenoceptor (β2-AR) gene (ADRB2) display functional effects that may be clinically relevant. Single nucleotide polymorphisms (SNPs) of ADBR2 are common and result in amino acid substitutions at positions 16, 27, and 164 of the receptor as well as position 19 of its 5′ upstream peptide. These SNPs… Expand
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