Genetic Variation of Genes Involved in Dihydrotestosterone Metabolism and the Risk of Prostate Cancer
@article{Setlur2010GeneticVO, title={Genetic Variation of Genes Involved in Dihydrotestosterone Metabolism and the Risk of Prostate Cancer}, author={Sunita R Setlur and Chen X. Chen and Ruhella R. Hossain and Jung Sook Ha and Vanessa Van Doren and Birgit Stenzel and Eberhard Steiner and Derek A. Oldridge and Naoki Kitabayashi and Samprit Banerjee and Jin Yun Helen Chen and Georg Sch{\"a}fer and Wolfgang Horninger and Charles Lee and Mark A. Rubin and Helmut Klocker and Francesca Demichelis}, journal={Cancer Epidemiology, Biomarkers \& Prevention}, year={2010}, volume={19}, pages={229 - 239} }
Purpose: Dihydrotestosterone (DHT) is an important factor in prostate cancer (PCA) genesis and disease progression. Given PCA's strong genetic component, we evaluated the possibility that variation in genes involved in DHT metabolism influence PCA risk. Experimental Design: We investigated copy number variants (CNV) and single nucleotide polymorphisms (SNP). We explored associations between CNV of uridine diphospho-glucuronosyltransferase (UGT) genes from the 2B subclass, given their prostate…
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References
SHOWING 1-10 OF 57 REFERENCES
Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population.
- Biology, MedicineCancer detection and prevention
- 2006
Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate
- Biology, MedicineThe Pharmacogenomics Journal
- 2008
Results show the UGT2B17 deletion polymorphism is associated with prostate cancer risk, and the individuals homozygous for the insertion allele expressed 30 times more UGT1B17 mRNA in prostate tissue than the heterozygotes.
Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.
- Medicine, BiologyUrology
- 2007
Association among polymorphisms in the steroid 5alpha-reductase type II (SRD5A2) gene, prostate cancer risk, and pathologic characteristics of prostate tumors in an Ecuadorian population.
- Biology, MedicineCancer genetics and cytogenetics
- 2009
Deletion Polymorphism of UDP-Glucuronosyltransferase 2B17 and Risk of Prostate Cancer in African American and Caucasian Men
- Biology, MedicineCancer Epidemiology Biomarkers & Prevention
- 2006
It is suggested that the UGT2B17 enzyme may play a role in the metabolism of androgens in prostate tissue and that the deletion polymorphism is associated with prostate cancer risk.
The UGT2B17 gene deletion polymorphism and risk of prostate cancer. A case-control study in Caucasians.
- Biology, MedicineCancer detection and prevention
- 2007
Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer.
- Biology, MedicineThe Journal of urology
- 2004
The results suggest that the UGT2B15 enzyme may have a role in the metabolism of dihydrotestosterone in prostate tissue and UGT1B15 Asp85Tyr polymorphism is associated with prostate cancer risk.
An Allele-Specific Polymerase Chain Reaction Method for the Determination of the D85Y Polymorphism in the Human UDPGlucuronosyltransferase 2B15 Gene in a Case-Control Study of Prostate Cancer
- Biology, MedicineAnnals of Surgical Oncology
- 2000
The results suggest that individuals who are homozygous for the lower activity D85 UGT2B15 allele may be at increased risk for developing prostate cancer, and an allele-specific polymerase chain reaction (PCR) assay was developed and validated.
Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA
- Medicine, BiologyThe Lancet
- 1999
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
- BiologyNature Genetics
- 2007
Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295.