Genetic Variation of Genes Involved in Dihydrotestosterone Metabolism and the Risk of Prostate Cancer

@article{Setlur2010GeneticVO,
  title={Genetic Variation of Genes Involved in Dihydrotestosterone Metabolism and the Risk of Prostate Cancer},
  author={S. Setlur and C. Chen and Ruhella R Hossain and J. Ha and V. Van Doren and Birgit Stenzel and E. Steiner and D. Oldridge and N. Kitabayashi and S. Banerjee and J. Chen and G. Sch{\"a}fer and W. Horninger and C. Lee and M. Rubin and H. Klocker and F. Demichelis},
  journal={Cancer Epidemiology, Biomarkers & Prevention},
  year={2010},
  volume={19},
  pages={229 - 239}
}
Purpose: Dihydrotestosterone (DHT) is an important factor in prostate cancer (PCA) genesis and disease progression. Given PCA's strong genetic component, we evaluated the possibility that variation in genes involved in DHT metabolism influence PCA risk. Experimental Design: We investigated copy number variants (CNV) and single nucleotide polymorphisms (SNP). We explored associations between CNV of uridine diphospho-glucuronosyltransferase (UGT) genes from the 2B subclass, given their prostate… Expand
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