Genetic Variation of Genes Involved in Dihydrotestosterone Metabolism and the Risk of Prostate Cancer

  title={Genetic Variation of Genes Involved in Dihydrotestosterone Metabolism and the Risk of Prostate Cancer},
  author={Sunita R Setlur and Chen X. Chen and Ruhella R. Hossain and Jung Sook Ha and Vanessa Van Doren and Birgit Stenzel and Eberhard Steiner and Derek A. Oldridge and Naoki Kitabayashi and Samprit Banerjee and Jin Yun Helen Chen and Georg Sch{\"a}fer and Wolfgang Horninger and Charles Lee and Mark A. Rubin and Helmut Klocker and Francesca Demichelis},
  journal={Cancer Epidemiology, Biomarkers \& Prevention},
  pages={229 - 239}
Purpose: Dihydrotestosterone (DHT) is an important factor in prostate cancer (PCA) genesis and disease progression. Given PCA's strong genetic component, we evaluated the possibility that variation in genes involved in DHT metabolism influence PCA risk. Experimental Design: We investigated copy number variants (CNV) and single nucleotide polymorphisms (SNP). We explored associations between CNV of uridine diphospho-glucuronosyltransferase (UGT) genes from the 2B subclass, given their prostate… 

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