Genetic Variation in the Peroxisome Proliferator Activated Receptor-Gamma Gene Is Associated with Histologically Advanced NAFLD

@article{Gawrieh2011GeneticVI,
  title={Genetic Variation in the Peroxisome Proliferator Activated Receptor-Gamma Gene Is Associated with Histologically Advanced NAFLD},
  author={Samer Gawrieh and Miranda C. Marion and Richard Komorowski and James Wallace and Michael Charlton and Ahmed H. Kissebah and Carl D. Langefeld and Michael Olivier},
  journal={Digestive Diseases and Sciences},
  year={2011},
  volume={57},
  pages={952-957}
}
The peroxisome proliferator activated receptor-gamma (PPARG) is a nuclear receptor that regulates adipocyte differentiation, insulin sensitivity and lipid metabolism, thus, it represents a good candidate gene for non-alcoholic fatty liver disease (NAFLD). We investigated the association of two PPARG variants (Pro12Ala and C1431T) with NAFLD and its histological features. DNA was extracted from 274 archived, formalin-fixed liver biopsy specimens from 212 patients with NAFLD and 62 controls with… CONTINUE READING
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