Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension

  title={Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension},
  author={Tien-Jyun Chang and Wen-Chang Wang and Chao A. Hsiung and Chih-Tsueng He and Ming-Wei Lin and Wayne Huey-Herng Sheu and Yi-Cheng Chang and Thomas Quertermous and Ida Y-D Chen and Jerome Rotter and Lee‐Ming Chuang},
AbstractEssential hypertension is a complex disease involving multiple genetic and environmental factors. A human gene containing a sorbin homology domain and 3 SH3 domains in the C-terminal region, termed SORBS1, plays a significant role in insulin signaling. We previously found a significant association between the T228A polymorphism and insulin resistance, obesity, and type 2 diabetes. It has been hypothesized that a set of genes responsible for insulin resistance may be closely linked with… 

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