Genetic Variation in the Α1a-adrenergic Receptor and Phenylephrine-mediated Venoconstriction

Abstract

There is large interindividual variability and ethnic differences in phenylephrine-mediated vasoconstriction. We tested the hypothesis that genetic variation in ADRA1A, the α1A adrenergic receptor gene, contributes to the variability and ethnic differences. We measured local dorsal hand vein responses to increasing doses of phenylephrine in 64 Caucasians… (More)
DOI: 10.1038/tpj.2014.69

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