Genetic Variation in Genes That Regulate T-Cell Differentiation and Function Is Associated with An Increased Risk of Developing B-Cell Non- Hodgkin Lymphoma

@article{Ansell2008GeneticVI,
  title={Genetic Variation in Genes That Regulate T-Cell Differentiation and Function Is Associated with An Increased Risk of Developing B-Cell Non- Hodgkin Lymphoma},
  author={Stephen M. Ansell and Anne J. Novak and Zhi-Zhang Yang and Zachary S. Fredericksen and Alice H. Wang and Neil E. Kay and Mark Liebow and Ahmet Dogan and Timothy G. Call and Thomas E. Witzig and Thomas M Habermann and Susan L. Slager and James R. Cerhan},
  journal={Blood},
  year={2008},
  volume={112},
  pages={3762-3762}
}
Background: B-cell non-Hodgkin lymphomas (NHL) are common lymphoid malignancies in which malignant B-cells arrested at various stages of differentiation proliferate within lymph nodes and occasionally other tissues. The microenvironment that supports the growth and survival of NHL B cells consists of a complex network of immune cells and cytokines and its specific composition has been shown to have significant clinical implications. The intratumoral immune cells include effector and regulatory… Expand
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This chapter covers the role of host genetic background in determining the risk of development of non-Hodgkin lymphoma (NHL) and summarizes the new developments on the relationship between the hostExpand