Genetic Variants of TSLP and Asthma in an Admixed Urban Population

  title={Genetic Variants of TSLP and Asthma in an Admixed Urban Population},
  author={Mengling Liu and L. Paige Rogers and Qinyi Cheng and Yongzhao Shao and Maria Elena Fernandez-Beros and Joel Hirschhorn and Helen N. Lyon and Zofia K. Z. Gajdos and Sailaja L Vedantam and Peter A. Gregersen and Michael F. Seldin and Bertram Bleck and Adaikalavan Ramasamy and A Hartikainen and Marjo-Riitta Jarvelin and Mikko Kuokkanen and Tarja Laitinen and Johan Eriksson and Terho Lehtim{\"a}ki and Olli T. Raitakari and Joan Reibman},
  booktitle={PloS one},
BACKGROUND Thymic stromal lymphopoietin (TSLP), an IL7-like cytokine produced by bronchial epithelial cells is upregulated in asthma and induces dendritic cell maturation supporting a Th2 response. Environmental pollutants, including tobacco smoke and diesel exhaust particles upregulate TSLP suggesting that TSLP may be an interface between environmental pollution and immune responses in asthma. Since asthma is prevalent in urban communities, variants in the TSLP gene may be important in asthma… CONTINUE READING
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