Genetic Variants of SARS-CoV-2-What Do They Mean?

@article{Lauring2021GeneticVO,
  title={Genetic Variants of SARS-CoV-2-What Do They Mean?},
  author={Adam S. Lauring and Emma B. Hodcroft},
  journal={JAMA},
  year={2021}
}
Over the course of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the clinical, scientific, and public health communities have had to respond to new viral genetic variants. Each one has triggered a flurry of media attention, a range of reactions from the scientific community, and calls from governments to either “stay calm” or pursue immediate countermeasures. While many scientists were initially skeptical about the significance of the D614G alteration, the emergence… 
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References

SHOWING 1-10 OF 12 REFERENCES
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
TLDR
The current dominant structural variant of SARS-CoV-2 appears to have evolved from the ancestral form and enhances transmissibility, and the mutation renders the new virus variant more susceptible to neutralizing antisera without altering the efficacy of vaccine candidates currently under development.
Transmission of SARS-CoV-2 on mink farms between humans and mink and back to humans
TLDR
The SARS-CoV-2 virus was initially introduced by humans and has since evolved, most likely reflecting widespread circulation among mink in the beginning of the infection period, several weeks before detection.
Spike mutation D614G alters SARS-CoV-2 fitness
TLDR
Hamsters infected with SARS-CoV-2 expressing spike D614G (G614 virus) produced higher infectious titres in nasal washes and the trachea, but not in the lungs, supporting clinical evidence showing that the mutation enhances viral loads in the upper respiratory tract of COVID-19 patients and may increase transmission.
D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.
TLDR
Sera from Spike-immunized mice, nonhuman primates and humans were evaluated for neutralization of pseudoviruses bearing either D614 or G614 Spike on their surface, indicating this is not an escape mutation that would impede current vaccines.
We shouldn’t worry when a virus mutates during disease outbreaks
TLDR
In reality, mutations are a natural part of the virus life cycle and rarely impact outbreaks dramatically, so discussions of mutations thrive during virus outbreaks, including the ongoing spread of SARS-CoV-2.
Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England
TLDR
The estimates suggest that control measures of a similar stringency to the national lockdown implemented in England in November 2020 are unlikely to reduce the effective reproduction number Rt to less than 1, unless primary schools, secondary schools, and universities are also closed.
European Centre for Disease Prevention and Control.
  • R. Evans
  • Medicine, Business
    Nursing standard (Royal College of Nursing (Great Britain) : 1987)
  • 2014
The European Centre for Disease Prevention and Control was set up in 2005 to strengthen Europe's defences against infectious diseases. The centre is an independent agency of the European Union and is
Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations
  • Virological.org
...
...