Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression

  title={Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression},
  author={Sher L. Hendrickson and J. A. Lautenberger and Leslie Wei Chinn and Michael J Malasky and E Sezgin and Lawrence A. Kingsley and James Jerome Goedert and Gregory D Kirk and Edward Gomperts and Susan P Buchbinder and Jennifer L. Troyer and Stephen J. O'Brien},
  booktitle={PloS one},
BACKGROUND The human mitochondrial genome includes only 13 coding genes while nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, redox regulation, and energetics. Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presumed functional differences have been associated with differential AIDS progression. METHODOLOGY/PRINCIPAL FINDINGS Here we explore whether single nucleotide polymorphisms (SNPs) within… CONTINUE READING
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