Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk

@article{Ehret2011GeneticVI,
  title={Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk},
  author={Georg B. Ehret and Patricia B. Munroe and Kenneth M. Rice and Murielle Bochud and Andrew D. Johnson and Daniel I. Chasman and Albert Vernon Smith and Martin D. Tobin and Germaine C. Verwoert and Shih‐Jen Hwang and Vasyl Pihur and Peter Vollenweider and Paul F. O’Reilly and Najaf Amin and Jennifer L. Bragg-Gresham and Alexander Teumer and Nicole L. Glazer and Lenore J. Launer and Jing Hua Zhao and Yurii S. Aulchenko and Simon C. Heath and Siim S{\~o}ber and Afshin Parsa and Jian’an Luan and Pankaj Arora and Abbas Dehghan and Feng Zhang and Gavin J A Lucas and Andrew A. Hicks and Anne U. Jackson and John F. Peden and Toshiko Tanaka and Sarah H. Wild and Igor Rudan and Wilmar Igl and Yuri Milaneschi and Alex N. Parker and Cristiano Fava and John Campbell Chambers and Ervin R. Fox and Meena Kumari and Min Jin Go and Pim van der Harst and Wen Kao and Marketa Sj{\"o}gren and D. G. Vinay and Myriam Alexander and Yasuharu Tabara and Sue Shaw-Hawkins and Peter H Whincup and Yongmei Liu and Gang Shi and Johanna Kuusisto and Bamidele O. Tayo and Mark Seielstad and Xueling Sim and Khanh-Dung Hoang Nguyen and Terho Lehtim{\"a}ki and Giuseppe Matullo and Ying Wu and Tom R. Gaunt and N. Charlotte Onland-Moret and Matthew N. Cooper and Carl G. P. Platou and Elin Org and Rebecca Hardy and Santosh Dahgam and Jutta Palmen and Veronique Vitart and Peter S Braund and Tatiana Kuznetsova and Cuno S.P.M. Uiterwaal and Adebowale A. Adeyemo and Walter Palmas and Harry Campbell and Barbara Ludwig and Maciej Tomaszewski and Ioanna Tzoulaki and Nicholette D. Palmer and Thor Aspelund and Melissa E. Garcia and Yen-Pei Christy Chang and Jeffrey R. O'Connell and Nanette I. Steinle and Diederick E. Grobbee and Dan E. Arking and Sharon L. R. Kardia and Alanna C. Morrison and Dena G Hernandez and Samer S. Najjar and Wendy L McArdle and David Hadley and Morris J. Brown and John M. Connell and Aroon D. Hingorani and Ian N. M. Day and Deborah A. Lawlor and John P. Beilby and Robert Lawrence and Robert J. Clarke and Jemma C. Hopewell and Halit Ongen and Albert W Dreisbach and Yali Li and J. Hunter Young and Joshua C Bis and Mika K{\"a}h{\"o}nen and Jorma S. Viikari and Linda S Adair and Nanette R. Lee and Ming-Huei Chen and Matthias Olden and Cristian Pattaro and Judith A Hoffman Bolton and Anna K{\"o}ttgen and Sven Bergmann and Vincent Mooser and Nish Chaturvedi and Timothy M. Frayling and Muhammad Islam and Tazeen Hasan Jafar and Jeanette Erdmann and Smita R. Kulkarni and Stefan R. Bornstein and J{\"u}rgen Gr{\"a}ssler and Leif C Groop and Benjamin F. Voight and Johannes Kettunen and Philip N. Howard and Andrew W. Taylor and Simonetta Guarrera and Fulvio Ricceri and Valur Emilsson and Andrew S. Plump and In{\^e}s Barroso and Kay-Tee Khaw and Alan B. Weder and Steven C. Hunt and Yan V. Sun and Richard N. Bergman and Francis S. Collins and Lori L Bonnycastle and Laura J. Scott and Heather M. Stringham and Leena Peltonen and Markus Perola and Erkki Vartiainen and Stefan-Martin Brand and Jan A. Staessen and Thomas J. Wang and Paul R. Burton and Mar{\'i}a Soler Artigas and Yanbin Dong and Harold Snieder and Xiao-ling Wang and Haidong Zhu and Kurt K. Lohman and Megan E. Rudock and Susan R. Heckbert and Nicholas L. Smith and Kerri L. Wiggins and Ayo Doumatey and Daniel Shriner and Gudrun Veldre and Margus Viigimaa and Sanjay Kinra and Dorairaj Prabhakaran and Vikal Tripathy and Carl D. Langefeld and Annika Rosengren and Dag S. Thelle and Anna Maria Corsi and Andrew B. Singleton and Terrence E Forrester and Gina Marie Hilton and Colin A Mckenzie and Tunde Salako and Naoharu Iwai and Yoshikuni Kita and Toshio Ogihara and Takayoshi Ohkubo and Tomonori Okamura and Hirotsugu Ueshima and Satoshi Umemura and Susana Eyheramendy and Thomas Heinz Meitinger and Heinz-Erich Wichmann and Yoon Shin Cho and Hyung-Lae Kim and Jong-Young Lee and James G. Scott and Joban S. Sehmi and Weihua Zhang and Bo Hedblad and Peter M. Nilsson and George Davey Smith and Andrew Wong and Narisu Narisu and Alena Stan{\vc}{\'a}kov{\'a} and Leslie J. Raffel and Jie Yao and Sekar Kathiresan and Christopher J. O’Donnell and Stephen M. Schwartz and Mohammad Arfan Ikram and William T. Longstreth and Thomas H. Mosley and Sudha Seshadri and Nick Shrine and Louise V. Wain and Mario A. Morken and Amy J. Swift and Jaana Laitinen and Inga Prokopenko and Paavo J. Zitting and Jackie A. Cooper and Steve E. Humphries and John Danesh and Asif Rasheed and Anuj Goel and Anders Hamsten and Hugh C. Watkins and Stephan J. L. Bakker and Wiek H. van Gilst and Charles S. Janipalli and K. Radha Mani and Chittaranjan S. Yajnik and Albert Hofman and Francesco U. S. Mattace-Raso and Ben A. Oostra and Ayşe Demirkan and Aaron Isaacs and Fernando Rivadeneira and Edward G. Lakatta and Marco Orru' and Angelo Scuteri and Mika Ala-Korpela and Antti J. Kangas and Leo-Pekka Lyytik{\"a}inen and Pasi Soininen and Taru Tukiainen and Peter W{\"u}rtz and Rick Twee-Hee Ong and Marcus D{\"o}rr and Heyo K. Kroemer and Uwe V{\"o}lker and Henry V{\"o}lzke and Pilar Galan and Serge Hercberg and Mark G. Lathrop and Diana Z{\'e}l{\'e}nika and Panos Deloukas and Massimo Mangino and Tim D. Spector and Guangju Zhai and James F. Meschia and Mike A. Nalls and Pankaj Sharma and Jano{\vs} Terzi{\'c} and Mallela Kranthi Kumar and Matthew Denniff and E A Zukowska-szczechowska and Lynne E. Wagenknecht and F. Gerald R. Fowkes and Fadi J. Charchar and Peter E H Schwarz and Caroline Hayward and Xiuqing Guo and Charles N. Rotimi and Michiel L. Bots and Eva Brand and Nilesh J. Samani and Ozren Pola{\vs}ek and Philippa J. Talmud and Fredrik Nyberg and Diana Kuh and Maris Laan and Kristian Hveem and Lyle J. Palmer and Yvonne T. van der Schouw and Juan Pablo Casas and Karen L. Mohlke and Paolo Vineis and Olli T. Raitakari and Santhi K. Ganesh and Tien Yin Wong and E. Shyong Tai and Richard S. Cooper and Markku Laakso and D. C. Rao and Tamara B. Harris and Richard W. Morris and Anna F. Dominiczak and Mika Kivimaki and Michael Marmot and Tetsuro Miki and Danish Saleheen and Giriraj Ratan Chandak and Josef Coresh and Gerjan J Navis and Veikko V Salomaa and Bok-ghee Han and Xiaofeng Zhu and Jaspal S Kooner and Olle Melander and Paul M. Ridker and Stefania Bandinelli and Ulf Gyllensten and Alan F. Wright and James F. Wilson and Luigi Ferrucci and Martin Farrall and Jaakko Tuomilehto and Peter P. Pramstaller and Roberto Elosua and Nicole Soranzo and Eric J G Sijbrands and David M Altshuler and Ruth J. F. Loos and Alan R. Shuldiner and Christian Gieger and Pierre Meneton and Andr{\'e} G. Uitterlinden and Nicholas J. Wareham and Vilmundur G. Gudnason and Jerome I. Rotter and Rainer Rettig and Manuela Uda and David P. Strachan and Jacqueline C. M. Witteman and A-L. Hartikainen and Jacques S. Beckmann and Eric Boerwinkle and Ramachandran S. Vasan and Michael Boehnke and Martin G. Larson and Marjo-Riitta J{\"a}rvelin and Bruce M. Psaty and Gonçalo R. Abecasis and Aravinda Chakravarti and Paul Elliott and Cornelia M. van Duijn and Christopher H. Newton-Cheh and Daniel Levy and Mark J. Caulfield and Toby Johnson},
  journal={Nature},
  year={2011},
  volume={478},
  pages={103 - 109}
}
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European… Expand
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  • R. Schnabel
  • Medicine, Biology
  • Circulation. Cardiovascular genetics
  • 2011
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The current knowledge of blood pressure genomics is appraised, the causal pathways for hypertension identified in Mendelian randomization studies are explored and the opportunities and challenges for drug repurposing and pharmacogenomics for the treatment of hypertension are highlighted. Expand
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