Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk

@inproceedings{Ehret2011GeneticVI,
  title={Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk},
  author={Georg B. Ehret and Patricia B. Munroe and Kenneth Rice and Murielle Bochud and Andrew D. Johnson and Daniel I. Chasman and Andrew Charles Smith and Martin D Tobin and Germaine C. Verwoert and S Hwang and Vasyl Pihur and Peter Vollenweider and Paul F. O'Reilly and Nikhil Amin and Jennifer L. Bragg-Gresham and Alexander Teumer and Nicole L. Glazer and William S. Kremen and Jing Hua Zhao and Yurii Aulchenko and Simon C. Heath and Siim S{\~o}ber and Amir Basiri Parsa and Jian'an Luan and Pankaj Arora and Abbas Dehghan and Fusuo Zhang and Guillaume Lucas and Andrew A Hicks and François Cambien and John F. Peden and Toshiyuki Tanaka and Sarah H. Wild and Ivar Reinvang and Wilmar Igl and Yuri Milaneschi and Alexander E. Parker and John Campbell Chambers and Edward J. Fox and M. Dharani Kumari and Min Jin Go and Pim van der Harst and William H. Kao and Marketa Sj{\"o}gren and D. G. Vinay and Myriam Alexander and Yasuharu Tabara and Sue Shaw-Hawkins and Peter H. Whincup and Yongmei Liu and Gang Shi and Johanna Kuusisto and Bamidele O. Tayo and Mark Seielstad and Xueling Sim and Khanh-Dung Hoang Nguyen and Terho Lehtim{\"a}ki and Giuseppe Matullo and Ying Wu and Tom R. Gaunt and N. Charlotte Onland-Moret and Matthew N Cooper and Carl G. P. Platou and Elin Org and Richard J. Hardy and Andrew A. Hicks and Jutta M Palmen and Andr{\'e} Uitterlinden and Peter Stuart Braund and Tatyana Kuznetsova and Cuno S.P.M. Uiterwaal and Ademola M. Adeyemo and Walter Palmas and Harry Lawrence Campbell and Barbara M. Ludwig and Maciej Tomaszewski and Ioanna Tzoulaki and Nicholette D Palmer and Thomas G. Aspelund and Melissa Speglic Zambrini Garcia and Yen-Pei Christy Chang and Jeffrey R. O'Connell and Nanette I. Steinle and Diederick E. Grobbee and Dan E Arking and Melanie Waldenberger and Alanna C. Morrison and Daniel Hern{\'a}ndez and Samer S. Najjar and Wendy L. Mcardle and David Putnam Hadley and S. Matthijs Boekholdt and John M. C. Connell and Aroon D. Hingorani and Ian N. M. Day and Deborah A. Lawlor and John P Beilby and Robert W. Lawrence and Robert Clarke and Jemma C Hopewell and Halit Ongen and Albert W Dreisbach and Yali Li and Jonathan H. Young and Joshua C Bis and Mika Kellis K{\"a}h{\"o}nen and Jorma Viikari and Linda S. Adair and Nanette R. Lee and Ming-Huei Chen and Matthias Olden and Cristian Pattaro and Judith A Hoffman Bolton and Anna K{\"o}ttgen and S{\'e}rgio Bergmann and Pier Angelica Merlini and Nalin A. Chaturvedi and Timothy M. Frayling and Muhammad Ahmad Mounir Islam and Tazeen Hasan Jafar and Jeanette Erdmann and Smita R. Kulkarni and Stefan R. Bornstein and Juergen Graessler and Leif Groop and Benjamin F. Voight and J Kettunen and Philip S. S. Howard and Andrew Taylor and Simonetta Guarrera and Filippo Ricceri and Valur Emilsson and Andrew S. Plump and In{\^e}s Barroso and Kay T Khaw and Alan B. Weder and Steven C. Hunt and Yan V. Sun and Richard N Bergman and Francis S. Collins and Lori L.C. Bonnycastle and Laura Jane Scott and Heather M Stringham and L. Peltonen and Markus Perola and Erkki Vartiainen and Sarah Brand and Jan A. Staessen and Thomas J. Wang and Paul R. Burton and Mar{\'i}a Soler Artigas and Yanbin Dong and Harold Snieder and Xiaoling Wang and Haidong Zhu and Kurt K. Lohman and Megan E. Rudock and Susan R. Heckbert and Nicholas L. Smith and Kerri L Wiggins and Ayo Doumatey and Daniel Shriner and Gudrun Veldre and Margus Viigimaa and Sanjay Kinra and Dorairaj Prabhakaran and Vikal Tripathy and Carl D. Langefeld and Annika Rosengren and Anna Maria Corsi and Andrew B. Singleton and Terrence Forrester and Gina M Hilton and Colin A Mckenzie and Tunde Salako and Naoharu Iwai and Yoshikuni Kita and Toshio Ogihara and Takayoshi Ohkubo and Tomonori Okamura and Hirotsugu Ueshima and Shinobu Umemura and Susana Eyheramendy and Thomas Meitinger and Heinz-Erich Wichmann and Hyung-Lae Kim and Jong-Young Lee and James Samson Scott and Joban S. Sehmi and Wei Zhang and Inger Nj{\o}lstad and Peter Nilsson and George Davey Smith and Thomas C. Wang and Narisu Narisu and Alena Stan{\vc}{\'a}kov{\'a} and Leslie J. Raffel and Joseph D.C. Yao and Sekar Kathiresan and Christopher J. O'Donnell and Stephen M Schwartz and M. Arfan Ikram and Will T Longstreth and Thomas H. Mosley and Sridhar S. Seshadri and Nick R. G. Shrine and Louise V Wain and Mario A. Morken and Amy J. Swift and Jaana Laitinen and Inga Prokopenko and Paavo Zitting and Jacqueline A. Cooper and John Danesh and Asif Al Rasheed and Anuj Goel and Anders Hamsten and Herbert Edmond Watkins and Stephan J L Bakker and Wiek H van Gilst and Charles Spurgeon Janipalli and Kulathu Radha Mani and Chittaranjan Yajnik and Albert Hofman and Francesco U.S. Mattace-Raso and Ben A. Oostra and Ayşe Demirkan and Arthur James David Isaacs and Fernando Rivadeneira and Edward G. Lakatta and Marco Orr{\'u} and Angelo Scuteri and Mika Ala-Korpela and Antti J. Kangas and L P Lyytik{\"a}inen and Pasi Soininen and Taru Tukiainen and Peter W{\"u}rtz and Rick Twee-Hee Ong and Marcus D{\"o}rr and Heyo Klaus Kroemer and Uwe V{\"o}lker and Henry Voelzke and Pilar Rom{\'a}n Gal{\'a}n and Serge Hercberg and Marie E. Lathrop and Diana Z{\'e}l{\'e}nika and Panos Deloukas and Massimo Mangino and Tim D. Spector and Guangju Zhai and James F. Meschia and Michael A. Nalls and Pankaj Sharma and Jenny Terzic and Mallela Kranthi Kumar and Fadi J. Charchar and E A Zukowska-szczechowska and Lynne E. Wagenknecht and F Gerald R Fowkes and Fadi J Charchar and Peter E. H. Schwarz and Catherine P M Hayward and Xiuqing Guo and Charles N Rotimi and Michiel L. Bots and Nilesh J. Samani and Ozren Pola{\vs}ek and Philippa J. Talmud and Fredrik Nyberg and Diana J Kuh and Marijke Laan and Kristian Hveem and Lyle J. Palmer and Yvonne T van der Schouw and Juan P. Casas and Karen L. Mohlke and Paolo Vineis and Olli Raitakari and Shivendranath Ganesh and Tien Yin Wong and E. Shyong Tai and Richard S. Cooper and Markku Laakso and Dr. Ch. Mallikarjuna Rao and Tamara B. Harris and Richard W. Morris and Anna F. Dominiczak and Mika Kivim{\"a}ki and Michael Marmot and Tetsuro Miki and Danish Saleheen and Giriraj Ratan Chandak and Josef Coresh and Shelly L. Smith and Veikko V Salomaa and Bok-ghee Han and Xiaofeng Zhu and Jaspal Singh Kooner and Olle Melander and Paul M. Ridker and Stefania Bandinelli and Ulf Gyllensten and Amanda Faith Wright and James F Wilson and Luigi Ferrucci and Martin Farrall and Jaakko O Tuomilehto and Peter P. Pramstaller and Roberto Elosua and Nicole Soranzo and Eric J.G. Sijbrands and David Altshuler and Ruth J. F. Loos and Alan R. Shuldiner and Christian Gieger and Pierre Meneton and Andr{\'e} G Uitterlinden and Nicholas J. Wareham and Vilmundur Gudnason and Jerome I. Rotter and Rainer Dr Rettig and Manuela Uda and D. P. Strachan and Jacqueline C. M. Witteman and Anna-Liisa Hartikainen and Jacques S. Beckmann and Eric Boerwinkle and Ramachandran S. Vasan and Michael Boehnke and Martin G. Larson and Marjo-Riitta J{\"a}rvelin and Bruce Mark Psaty and Gonçalo R. Abecasis and Aravinda Chakravarti and Paul Elliott and Cornelia M van Duijn and Stella Trompet and Deborah A. Levy and Mark J. Caulfield and Taiwo Johnson},
  booktitle={Nature},
  year={2011}
}
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European… CONTINUE READING
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