Genetic Variants and Increased Expression of Parascaris equorum P-glycoprotein-11 in Populations with Decreased Ivermectin Susceptibility

@inproceedings{Janssen2013GeneticVA,
  title={Genetic Variants and Increased Expression of Parascaris equorum P-glycoprotein-11 in Populations with Decreased Ivermectin Susceptibility},
  author={I. Jana I. Janssen and J{\"u}rgen Kr{\"u}cken and Janina Demeler and Marta Basiaga and Sławomir Kornaś and Georg von Samson-Himmelstjerna},
  booktitle={PloS one},
  year={2013}
}
Macrocyclic lactones (MLs) represent the major drug class for control of parasitic infections in humans and animals. However, recently reports of treatment failures became more frequent. In addition to human and ruminant parasitic nematodes this also is the case for the horse-nematode Parascaris equorum. Nevertheless, to date the molecular basis of ML resistance is still not understood. Unspecific resistance mechanisms involving transporters such as P-glycoproteins (Pgps) are expected to… CONTINUE READING
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