Genetic Variants Regulating Immune Cell Levels in Health and Disease

@article{Orr2013GeneticVR,
  title={Genetic Variants Regulating Immune Cell Levels in Health and Disease},
  author={Valeria Orr{\`u} and Maristella Steri and Gabriella Sole and Carlo Sidore and Francesca Virdis and Mariano Dei and Sandra Lai and Magdalena Zoledziewska and Fabio Busonero and Antonella Mulas and Matteo Floris and Wieslawa I. Mentzen and Silvana A.M. Urru and Stefania Olla and Michele Marongiu and Maria Grazia Piras and Monia Lobina and Andrea Maschio and Maristella Pitzalis and Maria Francesca Urru and Marco Marcelli and Roberto Cusano and Francesca Deidda and Valentina Serra and Manuela Oppo and Rosella Pilu and Fr{\'e}d{\'e}ric Reinier and Riccardo Berutti and Luca Pireddu and Ilenia Zara and Eleonora Porcu and Alan Kwong and Christine Brennan and Brendan J. Tarrier and R. Lyons and Hyun Min Kang and Sergio Uzzau and Rossano Atzeni and Maria Stella Valentini and Davide Firinu and Lidia Leoni and Gianluca Rotta and Silvia Naitza and Andrea Angius and Mauro Congia and Michael B. Whalen and Chris Jones and David Schlessinger and Gonçalo R. Abecasis and Edoardo Fiorillo and Serena Sanna and Francesco Cucca},
  journal={Cell},
  year={2013},
  volume={155},
  pages={242-256}
}
The complex network of specialized cells and molecules in the immune system has evolved to defend against pathogens, but inadvertent immune system attacks on "self" result in autoimmune disease. Both genetic regulation of immune cell levels and their relationships with autoimmunity are largely undetermined. Here, we report genetic contributions to quantitative levels of 95 cell types encompassing 272 immune traits, in a cohort of 1,629 individuals from four clustered Sardinian villages. We… CONTINUE READING
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