Genetic Variant of Human Erythrocyte Malate Dehydrogenase

@article{Davidson1967GeneticVO,
  title={Genetic Variant of Human Erythrocyte Malate Dehydrogenase},
  author={Ronald G. Davidson and Jean A. Cortner},
  journal={Nature},
  year={1967},
  volume={215},
  pages={761-762}
}
MALATE dehydrogenase exists in two distinct forms in a variety of mammalian tissues, one of which is in the cytoplasm as a soluble or supernatant enzyme and the other is tightly bound to the mitochondria1. These two forms have different chemical, physical and kinetic properties2–4 and each has a characteristic electrophoretic pattern5. Unlike most tissues erythrocytes possess only cytoplasmic malato dehydrogenase, as would be expected in the absence of mitochondria. This report concerns an… CONTINUE READING