Genetic Variability and the Classification of Hepatitis E Virus

@article{Smith2013GeneticVA,
  title={Genetic Variability and the Classification of Hepatitis E Virus},
  author={Donald B. Smith and M. Purdy and P. Simmonds},
  journal={Journal of Virology},
  year={2013},
  volume={87},
  pages={4161 - 4169}
}
ABSTRACT The classification of hepatitis E virus (HEV) variants is currently in transition without agreed definitions for genotypes and subtypes or for deeper taxonomic groupings into species and genera that could incorporate more recently characterized viruses assigned to the Hepeviridae family that infect birds, bats, rodents, and fish. These conflicts arise because of differences in the viruses and genomic regions compared and in the methodology used. We have reexamined published sequences… Expand
Classification and Genomic Diversity of Enterically Transmitted Hepatitis Viruses.
TLDR
There is, however, little evidence that variants of HAV or HEV differ antigenically or in their propensity to cause severe disease. Expand
The effect of phylogenetic signal reduction on genotyping of hepatitis E viruses of the species Orthohepevirus A
TLDR
This paper examines this practice with sequences from members of the species Orthohepevirus A, finding that while it is possible to correctly genotype sequences with short subgenomic sequences, the estimates of evolutionary relationships between genotypes degrade to such an extent that sequences below 1600 nucleotides long cannot be used reliably to study these relationships. Expand
Full-length sequence analysis of hepatitis E virus isolates: showing potential determinants of virus genotype and identity
TLDR
A broader comparison with other genotype isolates revealed that there are a few conserved amino acids in the HVR region of different HEV genotypes, and two amino acid motifs in ORF2 and ORF3 might serve as signatures of genotype diversity of HEV. Expand
Variability and pathogenicity of hepatitis E virus genotype 3 variants
TLDR
Comparisons of subgenomic sequences previously obtained from blood donors with those from patients presenting with hepatitis found no evidence for an association between variants of HEV-3 and disease severity or alanine aminotransferase level, suggesting a more important role for host factors in its clinical phenotype. Expand
Hepeviridae: an expanding family of vertebrate viruses.
TLDR
A suggestion for a new taxonomic grouping scheme of the viruses within the family Hepeviridae is presented, and a distantly related agent was described from closely related salmonid fish. Expand
Proposed reference sequences for hepatitis E virus subtypes.
TLDR
A table of proposed complete genome reference sequences for each hepatitis E virus subtype is provided to facilitate communication between researchers and help clarify the epidemiology of this important human pathogen. Expand
Classification of human and zoonotic group hepatitis E virus (HEV) using antigen detection
TLDR
E Evaluation of serial samples from HEV-infected rhesus monkeys indicated that HEV antigen-positive samples can be classified using the antigen-based classification method, and it has potentially important public health applications, especially in underdeveloped areas that cannot afford the high cost of nucleic acid testing. Expand
Diversity of hepatitis E virus genotype 3
TLDR
This study sequences new complete genome sequences of HEV‐3 that could be useful for comparing strains circulating in humans and the animal reservoir and investigates mutations in the polymerase gene. Expand
El virus de Hepatitis E en los animales domésticos: Una revisión
Hepatitis E virus (HEV) is an emerging pathogen, was originally identified as the agent of transmission of enteric hepatitis Non-A, Non-B, identified in pigs and humans. Hepatitis E virus (HEV),Expand
Molecular Characterization and Prevalence of Hepatitis E Virus in Swedish Wild Animals - A Zoonotic Perspective
TLDR
The introduction of a single amplicon PCR of near complete HEV genomes enabled the identification of possible virulence marker, and the detection of possible recombination events between Swedish swine and wild boar, and that there may have been zoonotic transmission of HEV strains between Spain and France. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 51 REFERENCES
Evidence for hepatitis E virus quasispecies.
TLDR
Data from a serum bank collected in Tanefdour, Algeria, during an acute hepatitis epidemic (1986-1987), retrospectively confirmed as hepatitis E, strongly support the quasispecies organization of HEV during epidemics and could explain the adaptable behaviour of the virus in the host-pathogen interrelations. Expand
Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis
TLDR
In most areas where HEV genotypes 3 and 4 were characterised, sequences from both humans and animals were highly conserved, indicating they originated from the same infectious sources. Expand
Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV).
TLDR
Knowing the extent of the sequence variation encountered with HEV will not only aid in the future development of diagnostic and vaccine reagents but also further the understanding of how HEV strain variation might impact the pathological outcome of infection. Expand
Evolution of the hepatitis E virus hypervariable region
TLDR
It is concluded that the range of HVR diversity observed within virus genotypes can be explained by the accumulation of substitutions and, to a much lesser extent, through deletions or duplications of this region. Expand
Genetic variability and evolution of hepatitis E virus.
TLDR
Current knowledge on the genomic variability, geographic distribution and zoonotic aspects of Hepevirus as well as the clinical significance of genotype and evolution of HEV are reviewed. Expand
Bats Worldwide Carry Hepatitis E Virus-Related Viruses That Form a Putative Novel Genus within the Family Hepeviridae
TLDR
Sequence- and distance-based taxonomic evaluations suggested that bat hepeviruses constitute a distinct genus within the family Hepeviridae and that at least three other genera comprising human, rodent, and avian hepe Viruses can be designated, which may imply that hepe viruses invaded mammalian hosts nonrecently and underwent speciation according to their host restrictions. Expand
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
TLDR
These proposals provide the framework by which the HCV databases store and provide access to data on HCV, which will internationally coordinate the assignment of new genotypes and subtypes in the future. Expand
Hepatitis E virus genotyping based on full-length genome and partial genomic regions.
TLDR
It was demonstrated with both one- way ANOVA and two-way ANOVA that only one genomic region in RNA-dependent RNA polymerase domain (4254-4560nt) for which there were no significant differences when compared with the full-length genome (P>0.05) was identified. Expand
The serological prevalence and genetic diversity of hepatitis E virus in farmed rabbits in China.
  • Y. Geng, Chenyan Zhao, +6 authors Youchun Wang
  • Biology, Medicine
  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2011
TLDR
The results indicate that rabbit HEVs with considerable genetic diversity are prevalent in farmed rabbits in China and the potential zoonotic risk of rabbit HEV needs to be investigated and evaluated further. Expand
Nomenclature and numbering of the hepatitis C virus.
TLDR
A group of experts in the field of HCV genetic variability, and those involved in development ofHCV sequence databases, drew up revised criteria for the assignment of new genotypes as they are discovered in the future and discussed how HCV sequences databases could introduce and facilitate a standardized numbering system. Expand
...
1
2
3
4
5
...