Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential

@inproceedings{Kyttl2016GeneticVO,
  title={Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential},
  author={Aija Kytt{\"a}l{\"a} and Roksana Moraghebi and Cristina Valensisi and Johannes Kettunen and Colin R. Andrus and Kalyan Kumar Pasumarthy and Mahito Nakanishi and Ken A. Nishimura and Manami Ohtaka and Jere Weltner and Ben Van Handel and Olavi Parkkonen and Juha Sinisalo and Anu Jalanko and R. David Hawkins and N B Woods and Timo Otonkoski and Ras Trokovic},
  booktitle={Stem cell reports},
  year={2016}
}
Reports on the retention of somatic cell memory in induced pluripotent stem cells (iPSCs) have complicated the selection of the optimal cell type for the generation of iPSC biobanks. To address this issue we compared transcriptomic, epigenetic, and differentiation propensities of genetically matched human iPSCs derived from fibroblasts and blood, two tissues of the most practical relevance for biobanking. Our results show that iPSC lines derived from the same donor are highly similar to each… CONTINUE READING
36 Citations
50 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Retinoic acid regulates hematopoietic development fromhumanpluripotent stemcells

  • R. E. Ronn, C. Guibentif, +4 authors N. B. andWoods
  • StemCell Rep
  • 2015
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…