Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation

  title={Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation},
  author={Erum Dilshad and Rosa Maria Cusido and Karla Ramirez Estrada and Mercedes Bonfill and Bushra Mirza and Tianzhen Zhang},
  booktitle={PloS one},
The potent antimalarial drug artemisinin has a high cost, since its only viable source to date is Artemisia annua (0.01-0.8% DW). There is therefore an urgent need to design new strategies to increase its production or to find alternative sources. In the current study, Artemisia carvifolia Buch was selected with the aim of detecting artemisinin and then enhancing the production of the target compound and its derivatives. These metabolites were determined by LC-MS in the shoots of A. carvifolia… CONTINUE READING
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