Genetic Susceptibility to Fungal Infections in Humans.

  title={Genetic Susceptibility to Fungal Infections in Humans.},
  author={Michail S. Lionakis},
  journal={Current fungal infection reports},
  volume={6 1},
Most fungal infections in humans occur in the setting of iatrogenic immunosuppression or HIV infection. In the absence of these factors, fungi cause mild, self-limited infections that typically involve mucocutaneous surfaces. Hence, when persistent or recurrent mucocutaneous infections (chronic mucocutaneous candidiasis [CMC]) or invasive fungal infections (IFIs) develop in a "normal" host, they are indicative of genetic defects causing innate or adaptive immune dysfunction. In this review… CONTINUE READING
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