Genetic Susceptibility to Cardiac and Digestive Clinical Forms of Chronic Chagas Disease: Involvement of the CCR5 59029 A/G Polymorphism.

@article{Oliveira2015GeneticST,
  title={Genetic Susceptibility to Cardiac and Digestive Clinical Forms of Chronic Chagas Disease: Involvement of the CCR5 59029 A/G Polymorphism.},
  author={Amanda Priscila de Oliveira and C{\'a}ssia Rubia Bernardo and Ana Vit{\'o}ria da Silveira Camargo and Luiz S{\'e}rgio Ronchi and Aldenis Albaneze Borim and Cinara de C{\'a}ssia Brand{\~a}o de Mattos and Eumildo de Campos J{\'u}nior and L{\'i}lian Castiglioni and Jo{\~a}o Gomes Netinho and Carlos Eug{\^e}nio Cavasini and Reinaldo Bulgarelli Bestetti and L C de Mattos},
  journal={PloS one},
  year={2015},
  volume={10 11},
  pages={e0141847}
}
The clinical manifestations of chronic Chagas disease include the cardiac form of the disease and the digestive form. Not all the factors that act in the variable clinical course of this disease are known. This study investigated whether the CCR5Δ32 (rs333) and CCR5 59029 A/G (promoter region--rs1799987) polymorphisms of the CCR5 gene are associated with different clinical forms of chronic Chagas disease and with the severity of left ventricular systolic dysfunction in patients with chronic… CONTINUE READING
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