Genetic Susceptibility to Benzene Toxicity in Humans

@article{Garte2008GeneticST,
  title={Genetic Susceptibility to Benzene Toxicity in Humans},
  author={S. Garte and E. Taioli and T. Popov and C. Bolognesi and P. Farmer and F. Merlo},
  journal={Journal of Toxicology and Environmental Health, Part A},
  year={2008},
  volume={71},
  pages={1482 - 1489}
}
  • S. Garte, E. Taioli, +3 authors F. Merlo
  • Published 2008
  • Biology, Medicine
  • Journal of Toxicology and Environmental Health, Part A
Human metabolism of benzene involves pathways coded for by polymorphic genes. To determine whether the genotype at these loci might influence susceptibility to the adverse effects of benzene exposure, 208 Bulgarian petrochemical workers and controls, whose exposure to benzene was determined by active personal sampling, were studied. The frequency of DNA single-strand breaks (DNA-SSB) was determined by alkaline elution, and genotype analysis was performed for five metabolic loci. Individuals… Expand
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