• Corpus ID: 555463

Genetic Structure of the Purebred Domestic Dog

  title={Genetic Structure of the Purebred Domestic Dog},
  author={Dong Shen and Alberto and Bardelli and Jason A. Sager and Steve Szabo and Janine Ptak and Natalie and Silliman and Brock A. Peters and Michiel S. Heijden and Gregory J Riggins and M. Steven and Powell and Sanford D. Markowitz and W. Beagley Kenneth and Kinzler},
PINK1 cDNA and a green fluorescent protein (GFP) reporter plasmid and then stressed with the peptide aldehyde Cbz-leu-leuleucinal (MG-132), which inhibits the proteasome and induces apoptosis via distinct mechanisms, including mitochondrial injury (8). Analysis of TMRM fluorescence in GFPpositive cells revealed that the PINK1 mutation had no significant effect on m under basal conditions (Fig. 3A). However, after stress with MG-132, there was a significant decrease in m from basal levels in… 

Figures from this paper

A SINE insertion causes the black-and-tan and saddle tan phenotypes in domestic dogs.

A mutation consisting of a short interspersed nuclear element (SINE) insertion in intron 1 of ASIP that allows for the differentiation of the a(w) wolf sable and a(t) black-and-tan alleles is characterized.

Frequency of the mutant MDR1 allele in dogs in the UK

The prevalence of rough collies with heterozygous MDR1 mutations is high, with the frequency of affected dogs varying slightly between geographical locations with allelic frequencies of 64 per cent reported in France, 59% in Germany, 58 per cent in Japan, and 56per cent in the USA.

A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs

A new mutation in MSTN found in the whippet dog breed that results in a double-muscled phenotype known as the “bully” whippets is described, marking the first time a mutation in the myostatin gene has been quantitatively linked to increased athletic performance.

The Domestic Cat, Felis catus, as a Model of Hereditary and Infectious Disease

With the development of genomic resources in the cat and the application of complementary comparative tools developed in other species, the domestic cat is emerging as a promising resource of phenotypically defined genetic variation of biomedical significance.

AMY2B Gene Copy-Number Variation Studied by Droplet Digital PCR (ddPCR) in Three Canids: Red Fox, Arctic Fox, and Chinese Raccoon Dog

The study showed that the multiplication of the AMY2B gene did not occur over several decades of breeding selection, which may reflect the low-starch feeding regime.

MITF and White Spotting in Dogs: A Population Study

None of the rare variants found in the coding sequence consistently occurred in dogs of any particular spotting pattern, but an insertion of a short interspersed nucleotide element (SINE) over 3000 bp 5# of the MITF-M start codon did fit with random spotting in many dog breeds.

Unexpected High Polymorphism at the FABP4 Gene Unveils a Complex History for Pig Populations

It is shown that high variability at the porcine FABP4 is the rule rather than the exception and Pig populations, even highly inbred, can maintain high levels of variability for surprisingly long periods of time.

Analysis of structural diversity in wolf-like canids reveals post-domestication variants

The authors' results provide insight into the evolution of structural variation in canines, where recombination is not regulated by PRDM9 due to the inactivation of this gene, and genes within the most differentiated CNV regions between dogs and wolves, which could reflect selection during the domestication process.

Genomic deletion of CNGB3 is identical by descent in multiple canine breeds and causes achromatopsia

An in-depth characterization of the achromatopsia phenotype in a new canine breed, the miniature Australian shepherd (MAS), revealed that the dog was homozygous for a complete genomic deletion of the CNGB3 gene, as has been previously observed in the AM.




Recently, many cellular oncogenes were identified in human cancerous cells by the DNA transfection method, some of which were found to contain sequences related with already known viral oncogenees.

… genetics …

A possible genetic aetiology to CSVT, provides reliable risk estimates and allows accurate comparison with genetic risk in other vascular conditions is supported.

The history and geography of human genes

  • R. Cann
  • Biology
    The Journal of Asian Studies
  • 1995
The author examines the history of human evolution in Africa, Europe, and Asia through the lens of genetic, archaeological, and linguistic information.


  • F. Maytag
  • Computer Science
    Arch. Mus. Informatics
  • 1996

Materials and methods are available as supporting material on Science Online

  • Materials and methods are available as supporting material on Science Online


  • Neuron
  • 2003

Supporting Online Material www.sciencemag.org/cgi/content/full

  • DC1 Materials and Methods Figs. S1 and S2 Tables S1 to S5
  • 1160