Genetic Structure of the Purebred Domestic Dog

@article{Parker2004GeneticSO,
  title={Genetic Structure of the Purebred Domestic Dog},
  author={Heidi G. Parker and Lisa Kim and Nathan B. Sutter and Scott J Carlson and Travis D. Lorentzen and Tiffany B. Malek and G S Johnson and Hawkins B. DeFrance and Elaine A. Ostrander and Leonid Kruglyak},
  journal={Science},
  year={2004},
  volume={304},
  pages={1160 - 1164}
}
We used molecular markers to study genetic relationships in a diverse collection of 85 domestic dog breeds. Differences among breeds accounted for ∼30% of genetic variation. Microsatellite genotypes were used to correctly assign 99% of individual dogs to breeds. Phylogenetic analysis separated several breeds with ancient origins from the remaining breeds with modern European origins. We identified four genetic clusters, which predominantly contained breeds with similar geographic origin… 

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References

SHOWING 1-10 OF 25 REFERENCES

Genetic structure of seven European cattle breeds assessed using 20 microsatellite markers.

It is demonstrated that a simple allele-sharing genetic distance parameter can be used to construct a dendrogram of relationships among animals and reflects an extensive underlying kinship structure, particularly for the Swiss Simmental breed and four breeds originating from the British Isles.

Genetic diversity of eleven European pig breeds

This study indicates that using genetic distances between breeds of farm animals in a classical taxonomic approach may not give clear resolution, but points to their usefulness in a prospective evaluation of diversity.

Multiple and ancient origins of the domestic dog.

Sequences from both dogs and wolves showed considerable diversity and supported the hypothesis that wolves were the ancestors of dogs, suggesting that dogs originated more than 100,000 years before the present.

Genetic Evidence for an East Asian Origin of Domestic Dogs

A larger genetic variation in East Asia than in other regions and the pattern of phylogeographic variation suggest an East Asian origin for the domestic dog, ∼15,000 years ago.

Genetic Structure of Human Populations

General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies.

Individual assignment using microsatellite DNA reveals unambiguous breed identification in the domestic dog.

This study explores the efficiency of the clustering methods in identifying the breeds of origin of 250 domestic dog individuals based on 10 microsatellite loci and refutes the traditional view that DNA based dog breed identification is not feasible at the individual level of resolution.

Empirical evaluation of genetic clustering methods using multilocus genotypes from 20 chicken breeds.

It is suggested that in species for which population structure is of interest, databases of multilocus genotypes at highly variable markers should be compiled and these genotypes could be used as training samples for genetic cluster analysis and to facilitate assignments of individuals of unknown origin to populations.

Ancient DNA Evidence for Old World Origin of New World Dogs

Mitochondrial DNA sequences isolated from ancient dog remains from Latin America and Alaska showed that native American dogs originated from multiple Old World lineages of dogs that accompanied late

Microsatellite analysis of population structure in Canadian polar bears

Using eight hypervariable microsatellite loci to study the genetic relationships between four Canadian polar bear populations indicates that gene flow between local populations is restricted despite the long‐distance seasonal movements undertaken by polar bears.

Unleashing the canine genome.

The modern dog offers key advantages over other animal systems for mapping genes relevant to human disease and the strong promise of linkagedisequilibrium (LD) mapping in dogs is focused on.