Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic, and Amygdala Dendritic Phenotypes

@article{Camp2012GeneticSD,
  title={Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic, and Amygdala Dendritic Phenotypes},
  author={Marguerite Charlotte Camp and Kathryn P. MacPherson and Lauren Lederle and Carolyn M Graybeal and Stefano Gaburro and Lauren Debrouse and Jessica L Ihne and Javier A. Bravo and Richard M. O'Connor and St{\'e}phane Ciocchi and Cara L Wellman and Andreas L{\"u}thi and John F Cryan and Nicolas Singewald and Andrew M Holmes},
  journal={Neuropsychopharmacology},
  year={2012},
  volume={37},
  pages={1534-1547}
}
Mood and anxiety disorders develop in some but not all individuals following exposure to stress and psychological trauma. However, the factors underlying individual differences in risk and resilience for these disorders, including genetic variation, remain to be determined. Isogenic inbred mouse strains provide a valuable approach to elucidating these factors. Here, we performed a comprehensive examination of the extinction-impaired 129S1/SvImJ (S1) inbred mouse strain for multiple behavioral… CONTINUE READING

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