Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms

@inproceedings{MiguelYanes2011GeneticRR,
  title={Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms},
  author={Jos{\'e} M de Miguel-Yanes and Peter J. Shrader and Michael J. Pencina and Caroline Fox and Alisa Knodle Manning and Richard W. Grant and Jos{\'e}e Dupuis and Jose C Florez and Ralph B. D'Agostino and L. Adrienne Cupples and James B. Meigs},
  booktitle={Diabetes care},
  year={2011}
}
OBJECTIVE To test if knowledge of type 2 diabetes genetic variants improves disease prediction. RESEARCH DESIGN AND METHODS We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed over 34 years using pooled logistic regression models stratified by age (<50 years, diabetes cases = 144; or ≥50 years, diabetes cases = 302). Models included clinical risk factors and a 40-SNP weighted genetic risk score. RESULTS In people… CONTINUE READING

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Miguel-Yanes and Associates care.diabetesjournals.org DIABETES CARE

  • J Holmkvist, E Laurila, +27 authors S. Purcell
  • Diabetes Genetics Initiative of Broad Institute…
  • 2011

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