Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

@article{Bhattacharya2012GeneticRO,
  title={Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice},
  author={Aditi Bhattacharya and Hanoch Kaphzan and Amanda C Alvarez-Dieppa and J. Patrick Murphy and Philippe Pierre and Eric Klann},
  journal={Neuron},
  year={2012},
  volume={76},
  pages={325-337}
}
Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the etiology of FXS, but most lines of research on therapeutic strategies have targeted protein synthesis indirectly, far upstream of the translation machinery. We sought to perturb p70 ribosomal S6 kinase 1 (S6K1), a key translation initiation and elongation regulator, in FXS model mice. We found that genetic reduction of S6K1 prevented elevated… CONTINUE READING
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