Genetic Program of Neuronal Differentiation and Growth Induced by Specific Activation of NMDA Receptors

@article{Ghiani2006GeneticPO,
  title={Genetic Program of Neuronal Differentiation and Growth Induced by Specific Activation of NMDA Receptors},
  author={Cristina A. Ghiani and Luis Beltr{\'a}n-Parrazal and Daniela Sforza and Jemily Malvar and Akop Seksenyan and R. A. Cole and Desmond J. Smith and Andrew Charles and Pedro A. Ferchmin and J. S. De Vellis},
  journal={Neurochemical Research},
  year={2006},
  volume={32},
  pages={363-376}
}
Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMDA receptors on gene regulation in a neuronal model, we used primary neuronal cultures developed from embryonic rat cerebri in serum-free medium. Using Affymetrix Gene Arrays, we… 

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