Genetic Program of Neuronal Differentiation and Growth Induced by Specific Activation of NMDA Receptors
@article{Ghiani2006GeneticPO, title={Genetic Program of Neuronal Differentiation and Growth Induced by Specific Activation of NMDA Receptors}, author={Cristina A. Ghiani and Luis Beltr{\'a}n-Parrazal and Daniela Sforza and Jemily Malvar and Akop Seksenyan and R. A. Cole and Desmond J. Smith and Andrew Charles and Pedro A. Ferchmin and J. S. De Vellis}, journal={Neurochemical Research}, year={2006}, volume={32}, pages={363-376} }
Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMDA receptors on gene regulation in a neuronal model, we used primary neuronal cultures developed from embryonic rat cerebri in serum-free medium. Using Affymetrix Gene Arrays, we…
25 Citations
Regulation of transcription factors by nitric oxide in neurons and in neural-derived tumor cells
- BiologyProgress in Neurobiology
- 2008
A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation.
- BiologyExperimental cell research
- 2008
A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis
- Biology, PsychologyFront. Mol. Neurosci.
- 2015
This review examines the CREB family of transcription factors, including the different members and known signaling pathways, and highlights the role of CREB as a modulator of AHN, which could underlie its function in memory consolidation mechanisms.
Targeting CREB signalling in neurogenesis
- BiologyExpert opinion on therapeutic targets
- 2010
This review focuses on a number of recent discoveries identifying the role of the transcription factor cAMP response element binding (CREB) protein in regulating brain development and neurogenesis in the adult brain.
Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate
- BiologyBMC Genomics
- 2010
This is the first study attempting to define neuronal gene expression patterns in response to chronic, endogenous Glu hyperactivity at brain synapses, and patterns observed were characterized by a combination of responses to stress and stimulation of nerve growth, intracellular transport and recovery.
Summary of the AOP Molecular Initiating Event
- Biology, Psychology
- 2015
The molecular initiating event (MIE) is described as the binding of antagonist to NMDAR in neurons during synaptogenesis (development) in hippocampus (one of the critical brain structures for learning and memory formation).
Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
- Biology, Psychology
- 2016
The molecular initiating event (MIE) is described as the chronic binding of antagonist to NMDAR in neurons during synaptogenesis (development) in hippocampus (one of the critical brain structures for learning and memory formation) and is relevant to developmental neurotoxicity (DNT).
Effects of Treadmill Exercise Combined with MK 801 Treatment on Neuroblast Differentiation in the Dentate Gyrus in Rats
- Biology, PsychologyCellular and Molecular Neurobiology
- 2010
It is suggested that NR may be one of the important factors that modulate neuroblast differentiation during exercise in rats, and the number of DCX cells was significantly decreased in the subgranular zone of the DG.
AOP Title Binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Short name: Binding of antagonist to NMDARs impairs cognition
- Biology, Psychology
- 2015
The molecular initiating event (MIE) is described as the binding of antagonist to NMDAR in neurons during synaptogenesis (development) in hippocampus (one of the critical brain structures for learning and memory formation).
References
SHOWING 1-10 OF 75 REFERENCES
Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical culture
- BiologyJournal of neurochemistry
- 2006
Calcium imaging studies revealed that NMDA activated a sustained increase in intracellular calcium concentration in the majority of neurons, whereas nicotine evoked only a transient calcium increase in a smaller percentage of neuron, suggesting that the calcium signalling response was correlated with activation of gene expression.
Molecular mechanisms associated with long-term consolidation of the NMDA signals.
- BiologyLife sciences
- 2000
Brain-Derived Neurotrophic Factor-Induced Gene Expression Reveals Novel Actions of VGF in Hippocampal Synaptic Plasticity
- BiologyThe Journal of Neuroscience
- 2003
Increased expression in vitro predicted elevations in vivo: VGF and the IEGs increased after trace eyeblink conditioning, a hippocampal-dependent learning paradigm, which suggested that the VGF neuropeptides may regulate synaptic function.
A Complex Program of Striatal Gene Expression Induced by Dopaminergic Stimulation
- Biology, PsychologyThe Journal of Neuroscience
- 1998
Novel components of a complex, coordinated genetic program that is induced in striatal cells in response to various dopaminergic manipulations are identified, including CREM, CHOP, and MAP kinase phosphatase-1.
N-Methyl-d-aspartate Receptors Regulate a Group of Transiently Expressed Genes in the Developing Brain*
- BiologyThe Journal of Biological Chemistry
- 2001
The results suggest that highly specific NMDA receptor-dependent regulation of gene expression plays an important role in the transition from proliferation of neuronal precursors to differentiation of neurons.
Regulation of neurogenesis by growth factors and neurotransmitters.
- BiologyJournal of neurobiology
- 1998
The findings discussed here indicate that proliferation and cell fate determination in the developing brain are regulated extrinsically by complex interactions between a relatively large number of growth factors and neurotransmitters.
Developmentally Regulated NMDA Receptor-Dependent Dephosphorylation of cAMP Response Element-Binding Protein (CREB) in Hippocampal Neurons
- BiologyThe Journal of Neuroscience
- 2000
It is suggested that, during neuronal maturation, NMDA receptor activation becomes linked specifically to protein phosphatases that act on Ser-133 of CREB, contributing to the changes in neural plasticity observed during brain development.
Numerous candidate plasticity-related genes revealed by differential cDNA cloning
- BiologyNature
- 1993
A highly sensitive differential complementary DNA cloning procedure is used to identify genes that may participate in long-term plasticity, suggesting that strong neuronal activation leads to de novo synthesis of vesicular and other synaptic components.
Neural activity and immediate early gene expression in the cerebral cortex
- Biology
- 1999
An understanding of the mechanistic contribution of the IEG response to neuronal plasticity will provide information not only about basic developmental processes, and their disturbances in mental retardation, but may also contribute to new diagnostic and therapeutic approaches for these developmental disorders.