Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

@inproceedings{Kawaguchi2012GeneticPO,
  title={Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese},
  author={Takahisa Kawaguchi and Yoshio Sumida and Atsushi Umemura and Keitaro Matsuo and Meiko Takahashi and Toshinari Takamura and Kohichiroh Yasui and Toshiji Saibara and Etsuko Hashimoto and Miwa Kawanaka and Sumio Watanabe and Sumio Kawata and Yasuharu Imai and Miki Kokubo and Toshihide Shima and Hyohun Park and Hideo Tanaka and Kazuo Tajima and Ryo Yamada and Fumihiko Matsuda},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a subtype accompanying hepatocyte degeneration and fibrosis is classified as nonalcoholic steatohepatitis (NASH). NASH accounts for approximately 10-30% of NAFLD and causes a higher frequency of liver-related death, and its progression of NASH has been considered to be complex involving multiple genetic factors interacting with the environment… CONTINUE READING

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