Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn's Disease

Abstract

BACKGROUND We aimed to identify certain genes related to response to infliximab (IFX) and biomarkers to predict the IFX effect for Japanese Crohn's disease (CD) patients by performing an association study of single nucleotide polymorphisms (SNPs) in candidate genes in the interleukin- (IL-) 17 signaling pathway with response to IFX after 1 year of treatment. METHODS A total of 103 patients were divided into two groups, responders and nonresponders. Twenty-eight tag SNPs in 5 genes were genotyped. The frequencies of alleles and genotypes of each SNP were compared between responders and nonresponders in three different inheritance models. A genetic test was performed using a combination of the associated SNPs as biomarkers. RESULTS Multivariate logistic regression analysis indicated that the four variable factors, concomitant use of immunomodulators, penetrating disease, a G/G genotype of rs766748 in IL-17F, and a C/C or C/A genotype of rs1883136 in TRAF3IP2, independently contributed to response to IFX after 1 year of treatment. Genetic test using the polymorphisms of these genes perfectly predicted the responder and nonresponder CD patients with both concomitant use of immunomodulators and penetrating disease. CONCLUSION IL17F and TRAF3IP2 are one of IFX-related genes, useful as biomarkers of IFX response, and may be target molecules for new therapeutic drugs.

DOI: 10.1155/2015/416838

Extracted Key Phrases

9 Figures and Tables

Cite this paper

@inproceedings{Urabe2015GeneticPO, title={Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn's Disease}, author={Shigetoshi Urabe and Hajime Isomoto and Tetsuya Ishida and Kazumi Maeda and Tatsuo Inamine and Shinji Kondo and Norihide Higuchi and Kayoko Sato and Ryohei Uehara and Hiroyuki Yajima and Haruhisa Machida and Chun Chuan Chen and Yasuhiro Fukuda and Fuminao Takeshima and Kazuhiko Nakao and Kazuhiro Tsukamoto}, booktitle={BioMed research international}, year={2015} }