Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans–Induced Inflammation in Mouse Lungs

@article{Endo2016GeneticPN,
  title={Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans–Induced Inflammation in Mouse Lungs},
  author={Daiki Endo and Kenta Fujimoto and Rika Hirose and Hiroko Yamanaka and Mizuki Homme and Ken-ichi Ishibashi and Noriko N. Miura and Naohito Ohno and Yasuaki Aratani},
  journal={Inflammation},
  year={2016},
  volume={40},
  pages={123-135}
}
Patients with chronic granulomatous disease (CGD) have mutated phagocyte NADPH oxidase, resulting in reduced production of reactive oxygen species (ROS). While the mechanism underlying hyperinfection in CGD is well understood, the basis for inflammatory disorders that arise in the absence of evident infection has not been fully explained. This study aimed… CONTINUE READING