Genetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile

@inproceedings{Brouwer2011GeneticOM,
  title={Genetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile},
  author={Michael S. M. Brouwer and Philip J. Warburton and Adam Paul Roberts and Peter Mullany and Elaine Allan},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Clostridium difficile is the leading cause of hospital-associated diarrhoea in the US and Europe. Recently the incidence of C. difficile-associated disease has risen dramatically and concomitantly with the emergence of 'hypervirulent' strains associated with more severe disease and increased mortality. C. difficile contains numerous mobile genetic elements, resulting in the potential for a highly plastic genome. In the first sequenced strain, 630, there is one proven conjugative… CONTINUE READING
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