Genetic Modifiers of Cystic Fibrosis–Related Diabetes

  title={Genetic Modifiers of Cystic Fibrosis–Related Diabetes},
  author={Scott M Blackman and Clayton W. Commander and Christopher M. Watson and Kristin M. Arcara and Lisa J. Strug and Jaclyn R. Stonebraker and Fred A. Wright and Johanna M Rommens and Lei Sun and Rhonda G. Pace and Sarah A. Norris and Peter R. Durie and Mitchell L. Drumm and Michael R Knowles and Garry R. Cutting},
Diabetes is a common age-dependent complication of cystic fibrosis (CF) that is strongly influenced by modifier genes. We conducted a genome-wide association study in 3,059 individuals with CF (644 with CF-related diabetes [CFRD]) and identified single nucleotide polymorphisms (SNPs) within and 5' to the SLC26A9 gene that associated with CFRD (hazard ratio [HR] 1.38; P = 3.6 × 10(-8)). Replication was demonstrated in 694 individuals (124 with CFRD) (HR, 1.47; P = 0.007), with combined analysis… CONTINUE READING


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