Genetic Manipulation of Cell Death and Neuroplasticity Pathways in Traumatic Brain Injury

@article{Schoch2012GeneticMO,
  title={Genetic Manipulation of Cell Death and Neuroplasticity Pathways in Traumatic Brain Injury},
  author={Kathleen M. Schoch and Sindhu Kizhakke Madathil and Kathryn Saatman},
  journal={Neurotherapeutics},
  year={2012},
  volume={9},
  pages={323-337}
}
Traumatic brain injury (TBI) initiates a complex cascade of secondary neurodegenerative mechanisms contributing to cell dysfunction and necrotic and apoptotic cell death. The injured brain responds by activating endogenous reparative processes to counter the neurodegeneration or remodel the brain to enhance functional recovery. A vast array of genetically altered mice provide a unique opportunity to target single genes or proteins to better understand their role in cell death and endogenous… CONTINUE READING
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