Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.

  title={Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.},
  author={Jessica Zucman-Rossi and Augusto Villanueva and Jean-Charles Nault and Josep M Llovet},
  volume={149 5},
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its mortality has increased in Western populations, with a minority of patients diagnosed at early stages, when curative treatments are feasible. Only the multikinase inhibitor sorafenib is available for the management of advanced cases. During the last 10 years, there has been a clear delineation of the landscape of genetic alterations in HCC, including high-level DNA amplifications in chromosome 6p21 (VEGFA… CONTINUE READING
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