Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

@inproceedings{Weng2017GeneticIW,
  title={Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium},
  author={Lu-Chen Weng and Kathryn L. Lunetta and Martina M{\"u}ller-Nurasyid and Andrew Charles Smith and S{\'e}bastien Th{\'e}riault and Peter Ejvin Weeke and John Barnard and Joshua C Bis and Leo-Pekka Lyytik{\"a}inen and Marcus E. Kleber and Andreas Martinsson and Henry W. J. Lin and Michiel Rienstra and Stella Trompet and Bouwe P. Krijthe and Marcus D{\"o}rr and Derek Klarin and Daniel I. Chasman and Moritz F. Sinner and Melanie Waldenberger and Lenore J. Launer and Tamara B. Harris and Elsayed Z Soliman and Alvaro Alonso and Guillaume Par{\'e} and Pedro L. Teixeira and Joshua C. Denny and M Benjamin Shoemaker and David R Van Wagoner and Jonathan D Smith and Bruce M. Psaty and Nona Sotoodehnia and Kent D. Taylor and Mika K{\"a}h{\"o}nen and Kjell Nikus and Graciela E. Delgado and Olle Melander and Gunnar Engstr{\"o}m and J Yao and Xiuqing Guo and Ingrid E Christophersen and Patrick T Ellinor and Bastiaan Geelhoed and Niek Verweij and Peter W. Macfarlane and Ian W. Ford and Jan Heeringa and Oscar H Franco and Andr{\'e} G. Uitterlinden and Uwe V{\"o}lker and Alexander Teumer and Lynda M. Rose and Stefan K{\"a}{\"a}b and Vilmundur Gudnason and Dan E Arking and David Conen and Dan M. Roden and Mina K. Chung and Susan R. Heckbert and Emelia J Benjamin and Terho Lehtim{\"a}ki and Winfried M{\"a}rz and Jan Gustav Smith and Jerome I. Rotter and Pim van der Harst and J Wouter Jukema and Bruno Stricker and Stephan B. Felix and Christine M. Albert and Steven A Lubitz},
  booktitle={Scientific Reports},
  year={2017}
}
It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent… CONTINUE READING
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