Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

  title={Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium},
  author={Lu-Chen Weng and Kathryn L. Lunetta and Martina M{\"u}ller-Nurasyid and Andrew Charles Smith and S{\'e}bastien Th{\'e}riault and Peter Ejvin Weeke and John Barnard and Joshua C Bis and Leo-Pekka Lyytik{\"a}inen and Marcus E. Kleber and Andreas Martinsson and Henry W. J. Lin and Michiel Rienstra and Stella Trompet and Bouwe P. Krijthe and Marcus D{\"o}rr and Derek Klarin and Daniel I. Chasman and Moritz F. Sinner and Melanie Waldenberger and Lenore J. Launer and Tamara B. Harris and Elsayed Z Soliman and Alvaro Alonso and Guillaume Par{\'e} and Pedro L. Teixeira and Joshua C. Denny and M Benjamin Shoemaker and David R Van Wagoner and Jonathan D Smith and Bruce M. Psaty and Nona Sotoodehnia and Kent D. Taylor and Mika K{\"a}h{\"o}nen and Kjell Nikus and Graciela E. Delgado and Olle Melander and Gunnar Engstr{\"o}m and J Yao and Xiuqing Guo and Ingrid E Christophersen and Patrick T Ellinor and Bastiaan Geelhoed and Niek Verweij and Peter W. Macfarlane and Ian W. Ford and Jan Heeringa and Oscar H Franco and Andr{\'e} G. Uitterlinden and Uwe V{\"o}lker and Alexander Teumer and Lynda M. Rose and Stefan K{\"a}{\"a}b and Vilmundur Gudnason and Dan E Arking and David Conen and Dan M. Roden and Mina K. Chung and Susan R. Heckbert and Emelia J Benjamin and Terho Lehtim{\"a}ki and Winfried M{\"a}rz and Jan Gustav Smith and Jerome I. Rotter and Pim van der Harst and J Wouter Jukema and Bruno Stricker and Stephan B. Felix and Christine M. Albert and Steven A Lubitz},
  booktitle={Scientific Reports},
It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent… CONTINUE READING
Twitter Mentions


Publications referenced by this paper.

Atrial fibrillation and risk of stroke: a nationwide cohort study.

  • Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2016